misfolded protein

Sometimes described as “cellular housekeeping”, autophagy — meaning “self-eating” in Greek – is a process that takes place in all mammalian cells and tissues. It was in the 1960s that researchers first became aware that each cell can destroy its own components. These components include damaged proteins and organelles, considered to be “common features of neurodegenerative diseases”, such as Alzheimer’s, Parkinson’s and Huntington’s disease.